Current Issue : April - June Volume : 2014 Issue Number : 2 Articles : 9 Articles
Fast dissolving oral dispersible films is a new type of delivery system also known as fast dissolving or disintegrating film for the oral delivery of the drugs which came into existence in 1970�s as an alternative to conventional tablets, capsules and syrups for paediatric and geriatric patients, who experience difficulties in swallowing solid dosage forms which has both the advantages of conventional tablet and of liquid formulation. Now a days fast dissolving oral films are used over conventional tablets and capsules to increase the patient compliance. Fast dissolving oral films consists of very thin film which gets dissolved in less than one minute when placed on the tongue. These are mostly used in delivering vitamins, vaccines and drug products which are widely accepted by the consumers. The present review reveals on various fast dissolving oral dispersible films and methods used in the formulation along with the evaluation parameters and a review was performed on the various fast dissolving oral film patents....
The purpose of this research was to develop and evaluate self- micro emulsifying drug delivery system (SMEDDS) of Olmesartan medoxomil (OLM), a highly lipophilic anti- hypertensive compound. SMEDDS were prepared by combining oil, surfactant and co solvent in different ratios. 26 ratios were prepared from which only 3 ratios were passed for characterization. The prepared SMEDDS were characterized by stability studies, percentage transmittance, droplet size measurement, coalescence study and dissolution study of liquid SMEDDS in water. Two ratios were failed in stability studied.. The in-vitro release study was performed in buffer pH 7.4. The globule size was found > 50 nm. The infrared spectra showed the absence of drug-polymer interactions. The result of this study demonstrates that this drug OLM can be successfully formulated as SMEDDS formulation to increase its dissolution....
The increasing need for patient compliance and convenience related research and a new method is the development of Mouth dissolving films, which dissolve instantly in patient�s oral cavity. Approximately 15 million to 30 million people suffer from Erectile Dysfunction and phosphodiesterase type 5 enzyme (PDE5) inhibitors are extensively used for the treatment of erectile dysfunction (ED). Mouth dissolving films are used for improving bioavailability with reducing time required to reach mouth plasma peak levels, which in turn reduces side effects and makes it cost effective. The Film containing PDE5 inhibitors like sildenafil, tadalafil and verdanafil will dissolve or disintegrate within seconds and instantaneously show its effect. Therefore PDE5 enzyme inhibitors will be beneficial over all other formulations....
In the present research work, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug, Risperidone by solid dispersion method using mannitol(1:1), Urea(1:1), PEG4000(1:1), PEG6000(1:2), PVPK30(1:4) as a carrier with varying drug: carrier ratios. Evaluation of solid dispersion i.e. in vitro- dissolution, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), X-ray diffraction (XRD) was performed. The solid dispersion of PEG 4000(1:1) showed the best cumulative drug release. The solid dispersions were then formulated as fast dissolving tablets by using 22factorial design and were subjected to various preformulation and post formulations studies. The evaluation of tablet batches i.e. wetting time, disintegrating time, hardness, friability, drug content, in vitro release, and stability parameters have been studied. After the evaluation of all four batches, the F2 batch shows the best cumulative release (99.58%) and also disintegration time (14 sec). From this study, it can be concluded that dissolution rate of risperidone could be enhanced by tablets containing solid dispersion by direct compression technique....
Once a daily proto-type gastro retentive dosage forms of Metoprolol tartrate (MT); �Ÿ1-selective adrenergic blocking agent was developed to increase the gastric retention, extend the drug release and to improve its oral bioavailability. Gastro retentive dosage forms (GRDF) were formulated using Hydroxy Propyl Methyl Cellulose (HPMC K100M) a synthetic polymer and Xanthan gum (XG) a natural polymer as drug release retardant and NaHCO3 as gas generating agent. The tablets were prepared by direct compression method and evaluated for various physico-chemical/mechanical parameters. Based on drug release kinetics, it can be concluded that the floating tablet containing 35%w/w HPMC K100M as the release retardant, Micro crystalline cellulose (Avicel PH 101) as filler and 20%w/w NaHCO3 as gas generating agent was a particularly suitable gastro retentive drug delivery system with a first order release profile....
The purpose of this research was to formulate and evaluate Ophthalmic In situ gel of Brinzolamide. The main objective of the present study was to increase the Precorneal retention for prolonging the release of drug. A drug delivery system for antiglaucomic agent Brinzolamide was developed utilizing concepts of sustained release, in order to obtain a unique drug delivery system which could remain in the precorneal surface of the eye for a longer period of time. For the development of ophthalmic in situ gel of anti glaucomic agent Brinzolamide, polymers used were HPMC E50LV as a viscosity enhancer and Sodium Alginate as a gelling agent. Disodium Hydrogen Phosphate and citric acid were used as buffer salts. The ophthalmic in situ gel was evaluated for various parameters such as gelling capacity, pH, Viscosity, % drug content and % in vitro drug release profile showed the satisfactory results for all the parameters. The optimized batch showed best gelling capacity, 99.3�±2.21% drug content and 98.03�±3.28 cumulative % drug release over 8 hr. Thus the ophthalmic in situ gel of anti glaucomic agent Brinzolamide was successfully formulated to obtain precorneal retention as well as prolong release of the drug....
The purpose of the present study was to prolong the gastric residence time of Famotidine by developing gastric floating drug delivery system (GFDDS). And to study influence of different polymers on its release rate. using gas-forming agents, like sodium bicarbonate, citric acid. Floating tablets were prepared by wet granulation method using PVP K-30 as a binder and the other polymers include Xanthan Gum, HPMC K100M, six different formulations with the varying concentrations of polymers were prepared and the tablets were evaluated in terms of their precompression parameters like bulk density, tapped density, Haunsner ratio,angle of repose, compressibility index, post compression physical characteristics, in vitro release, buoyancy, floating lag time (FLT), total floating time (TFT) and swelling index. All the formulations showed good floating lag time i.e. less than 3 mins. The batch containing combination of Xanthan Gum and HPMC 100M (i.e. F-6) showed total floating lag time more than 12 h., the highest swelling index among all the prepared batches (i.e. 230 %).The drug release was found to follow zero order kinetics....
The present investigation an attempt have been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing sustained release matrix tablets of Ritonavir. Sustained release matrix tablets of ritonavir were developed by using different polymer like hydroxyl propyl methyl cellulose(K100M) , Eudragit RS 100, chitosan, in different ratio formulations were compressed by wet granulation method. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, invitro dissolution. The in vitro drug release characteristics were studied in both simulated gastric and intestinal fluids for a period of 12 hr using USP Type 2 dissolution apparatus. drug in combination with chitosan were found to be effective in retarding the release of Ritonavir...
Among the orally disintegrating forms, Lozenges are solid preparations that are intended to dissolve or disintegrate slowly in the mouth. They contain one or more medicaments, usually in a flavoured, sweetened base. They can be prepared by molding (gelatin and/or fused sucrose or sorbitol base) or by compression of sugar-based tablets. Molded lozenges are sometimes referred to as Pastilles while compressed lozenges are often referred to as Troches. They are usually intended for treatment of local irritation or infections of the mouth or throat but may contain active ingredients intended for systemic absorption after swallowing. Molded lozenges have a softer texture because they contain a high percentage of sugar or a combination of a gelatin and sugar....
Loading....